Statins are prescription drugs used to lower cholesterol. Depending on which drug your doctor prescribes, you might not have to give up grapefruit at all. This doesn’t mean that you have to avoid grapefruit altogether if you’re prescribed this medication. The drugs that can interact with this citrus fruit includes statins. So, which medications should you avoid mixing with grapefruit and grapefruit juice? More of the drug in your bloodstream can cause certain side effects and affect how well the drug works. This is dangerous.Ī slower breakdown of a drug means you’ll have more of that drug in your bloodstream. Food and Drug Administration (FDA), grapefruit can affect the rate that your liver processes drugs. However, have you heard that you shouldn’t mix grapefruit and certain medications? As it turns out, this claim is true.Īccording to the U.S. It’s rich in antioxidants, vitamins, and fiber. Grapefruit is one of the healthiest citrus fruits you can eat. Substances Why You Shouldn’t Mix Grapefruit and Statins See all "Cited by" articles Publication types Kanwal U, Mukhtar S, Waheed M, Mehreen A, Abbas N, Shamim R, Hussain K, Rasool F, Hussain A, Bukhari NI. Review.įixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach. Vinci P, Panizon E, Tosoni LM, Cerrato C, Pellicori F, Mearelli F, Biasinutto C, Fiotti N, Di Girolamo FG, Biolo G. Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy. PMID: 36001213 Review.ĭietary Inhibitors of CYP3A4 Are Revealed Using Virtual Screening by Using a New Deep-Learning Classifier. PMID: 36193931 Free PMC article.Ī Review of Statin Intolerance: a Focus on Statin-Attributed Muscle Symptoms. Osula D, Wu B, Schesing K, Das SR, Moss E, Alvarez K, Clark C, Halm EA, Brown NJ, Vongpatanasin W. PMID: 20449528 Review.Ĭomparison of Pharmacy Refill Data With Chemical Adherence Testing in Assessing Medication Nonadherence in a Safety Net Hospital Setting. Vaquero MP, Sánchez Muniz FJ, Jiménez Redondo S, Prats Oliván P, Higueras FJ, Bastida S. Major diet-drug interactions affecting the kinetic characteristics and hypolipidaemic properties of statins. Rogers JD, Zhao J, Liu L, Amin RD, Gagliano KD, Porras AG, Blum RA, Wilson MF, Stepanavage M, Vega JM. Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similar articlesĮffects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. Keywords: Drug interaction Effect enhancer Grapefruit juice Ischemic heart disease LDL cholesterol Statins.Ĭopyright © 2016 Elsevier Inc. Grapefruit juice should not be contraindicated in people taking statins. The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.Ĩ mmol/L by 37%, reducing ischemic heart disease risk by 61%. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. 2 Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.Jonathan W Lee 1 , Joan K Morris 1 , Nicholas J Wald 2 Affiliations 1 Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.Jonathan W Lee 1 , Joan K Morris 1 , Nicholas J Wald 2 Home » Misc » Statins grapefruit interactions Statins grapefruit interactionsĭoi: 10.1016/j.amjmed.2015.07.036.
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